{"id":16419,"date":"2026-02-02T08:35:23","date_gmt":"2026-02-02T08:35:23","guid":{"rendered":"https:\/\/diyhaven858.wasmer.app\/index.php\/denosumab-use-linked-to-lower-knee-oa-risk-in-osteoporosis\/"},"modified":"2026-02-02T08:35:23","modified_gmt":"2026-02-02T08:35:23","slug":"denosumab-use-linked-to-lower-knee-oa-risk-in-osteoporosis","status":"publish","type":"post","link":"https:\/\/diyhaven858.wasmer.app\/index.php\/denosumab-use-linked-to-lower-knee-oa-risk-in-osteoporosis\/","title":{"rendered":"Denosumab Use Linked to Lower Knee OA Risk in Osteoporosis"},"content":{"rendered":"


\n<\/p>\n

\n
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TOPLINE:<\/h2>\n

In adults with osteoporosis, denosumab use vs bisphosphonate use was associated with a lower risk for incident knee osteoarthritis (OA), particularly among older adults and women.<\/p>\n

METHODOLOGY:<\/h2>\n
    \n
  • Researchers conducted a retrospective cohort study using data from the TriNetX US Collaborative Network to compare the risk for incident OA in adults with osteoporosis treated with denosumab vs bisphosphonates.<\/li>\n
  • They identified 360,283 adults aged 45 years or older who had at least two recorded osteoporosis diagnoses within 1 week before or after treatment initiation between January 2014 and December 2023.<\/li>\n
  • Overall, 59,157 denosumab users were matched on propensity score with 59,157 bisphosphonate users for analysis (nearly 88% female; nearly 75% White).<\/li>\n
  • The primary outcome was new-onset knee, hip, or thumb carpometacarpal OA.<\/li>\n
  • The 10-year risk for newly diagnosed OA was assessed in both treatment groups.<\/li>\n<\/ul>\n

    TAKEAWAY:<\/h2>\n
      \n
    • Denosumab use vs bisphosphonate use was associated with reduced risks for any OA (adjusted hazard ratio [HR], 0.96; 95% CI, 0.94-0.98) and knee OA (adjusted HR, 0.87; 95% CI, 0.84-0.91).<\/li>\n
    • No significant associations were noted between denosumab use and the incidence of hip OA or thumb carpometacarpal OA.<\/li>\n
    • Denosumab use was associated with a reduced incidence of knee OA in women (HR, 0.87; 95% CI, 0.83-0.91) but not in men.<\/li>\n
    • Significant associations were observed between the use of denosumab and the risk for incident OA \u2014 both any OA and knee OA \u2014 in participants older than 65 years (HR, 0.95; 95% CI, 0.92-0.97 and HR, 0.88; 95% CI, 0.84-0.91, respectively) but not in those aged 45-65 years.<\/li>\n<\/ul>\n

      IN PRACTICE:<\/h2>\n

      \u201cThese findings have important implications for tailoring individualized drug management of knee OA,\u201d the authors of the study wrote.<\/p>\n

      SOURCE:<\/h2>\n

      The study was led by Zhaohua Zhu, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China. It was published online on January 9, 2026, in Osteoarthritis and Cartilage<\/em>.<\/p>\n

      LIMITATIONS:<\/h2>\n

      The study mainly included non-Hispanic White participants with higher socioeconomic status, which might have limited the generalizability of the findings. Residual confounding might have persisted despite propensity score matching. The study was observational in nature, and the lack of consistent longitudinal weight data might have affected the results.<\/p>\n

      DISCLOSURES:<\/h2>\n

      The study received financial support from the National Natural Science Foundation of China. One author reported consulting roles on scientific advisory boards for several pharmaceutical and therapeutic companies, including Pfizer, Eli Lilly and Company, TissueGene, and others, outside the submitted work.<\/p>\n

      This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n


      \n
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      TOPLINE: In adults with osteoporosis, denosumab use vs bisphosphonate use was associated with a lower risk for incident knee osteoarthritis (OA), particularly among older adults and women. METHODOLOGY: Researchers conducted a retrospective cohort study using data from the TriNetX US Collaborative Network to compare the risk for incident OA in adults with osteoporosis treated with […]<\/p>\n","protected":false},"author":1,"featured_media":16420,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-16419","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/dt_260202_denosumab_800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/16419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=16419"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/16419\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/16420"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=16419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=16419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=16419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}