TOPLINE:<\/h2>\n
Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who presented with antimyeloperoxidase (anti-MPO) ANCA appeared to have a higher risk for major adverse cardiovascular events (MACE) and a shorter time to their occurrence than those who presented with antiproteinase 3 (anti-PR3) ANCA.<\/p>\n
METHODOLOGY:<\/h2>\n\n- Researchers conducted a retrospective observational study of 402 patients with AAV (mean age at diagnosis, 61 years; 55% men) who were treated at two French hospitals between January 2011 and March 2021.<\/li>\n
- Patients were stratified by ANCA specificity, of whom 236 were positive for anti-MPO ANCA and 166 positive for anti-PR3 ANCA.<\/li>\n
- Patients were followed up for a mean of 7.5 years.<\/li>\n
- The primary outcome was MACE, defined as the occurrence of myocardial infarction, stroke, or all-cause death.<\/li>\n<\/ul>\n
TAKEAWAY:<\/h2>\n\n- During follow-up, 78 incidences of MACE occurred. The incidence rate of MACE was higher in the anti-MPO ANCA group than in the anti-PR3 ANCA group (33.1 vs 21.4 per 1000 patient-years; P<\/em> = .036).<\/li>\n
- The mean time elapsed between the diagnosis of AAV and the occurrence of the first MACE was shorter in the anti-MPO ANCA group than in the anti-PR3 ANCA group (6.1 vs 7.6 years; P<\/em> < .001), with a similar pattern observed for myocardial infarction and stroke.<\/li>\n
- The presence of anti-PR3 ANCA was associated with a lower risk for stroke (adjusted hazard ratio, 0.61; P\u00a0<\/em>= .049); no such association was observed for myocardial infarction.<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
“[The study] findings further support the existence of distinct phenotypic and prognostic differences in AAV based on ANCA specificity and the need for developing a more patient-tailored management,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jon Idoate Lacasia, Internal Medicine, H\u00f4pital Tenon, Paris, France. It was published online on January 22, 2026, in RMD Open<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
The study’s retrospective design limited data collection. The cause of death could not be determined for nearly half of deaths recorded during follow-up. The lack of homogeneity in patient-level data prevented the inclusion of important variables such as proteinuria and cumulative glucocorticoid dose.<\/p>\n
DISCLOSURES:<\/h2>\n
The study did not receive any specific funding. The authors did not declare having any competing interests.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who presented with antimyeloperoxidase (anti-MPO) ANCA appeared to have a higher risk for major adverse cardiovascular events (MACE) and a shorter time to their occurrence than those who presented with antiproteinase 3 (anti-PR3) ANCA. METHODOLOGY: Researchers conducted a retrospective observational study of 402 patients with AAV […]<\/p>\n","protected":false},"author":1,"featured_media":17151,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty-260127-woman-having-heart-ache-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17150"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17151"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
TAKEAWAY:<\/h2>\n\n- During follow-up, 78 incidences of MACE occurred. The incidence rate of MACE was higher in the anti-MPO ANCA group than in the anti-PR3 ANCA group (33.1 vs 21.4 per 1000 patient-years; P<\/em> = .036).<\/li>\n
- The mean time elapsed between the diagnosis of AAV and the occurrence of the first MACE was shorter in the anti-MPO ANCA group than in the anti-PR3 ANCA group (6.1 vs 7.6 years; P<\/em> < .001), with a similar pattern observed for myocardial infarction and stroke.<\/li>\n
- The presence of anti-PR3 ANCA was associated with a lower risk for stroke (adjusted hazard ratio, 0.61; P\u00a0<\/em>= .049); no such association was observed for myocardial infarction.<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
“[The study] findings further support the existence of distinct phenotypic and prognostic differences in AAV based on ANCA specificity and the need for developing a more patient-tailored management,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jon Idoate Lacasia, Internal Medicine, H\u00f4pital Tenon, Paris, France. It was published online on January 22, 2026, in RMD Open<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
The study’s retrospective design limited data collection. The cause of death could not be determined for nearly half of deaths recorded during follow-up. The lack of homogeneity in patient-level data prevented the inclusion of important variables such as proteinuria and cumulative glucocorticoid dose.<\/p>\n
DISCLOSURES:<\/h2>\n
The study did not receive any specific funding. The authors did not declare having any competing interests.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who presented with antimyeloperoxidase (anti-MPO) ANCA appeared to have a higher risk for major adverse cardiovascular events (MACE) and a shorter time to their occurrence than those who presented with antiproteinase 3 (anti-PR3) ANCA. METHODOLOGY: Researchers conducted a retrospective observational study of 402 patients with AAV […]<\/p>\n","protected":false},"author":1,"featured_media":17151,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty-260127-woman-having-heart-ache-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17150"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17151"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
IN PRACTICE:<\/h2>\n
“[The study] findings further support the existence of distinct phenotypic and prognostic differences in AAV based on ANCA specificity and the need for developing a more patient-tailored management,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jon Idoate Lacasia, Internal Medicine, H\u00f4pital Tenon, Paris, France. It was published online on January 22, 2026, in RMD Open<\/em>.<\/p>\n The study’s retrospective design limited data collection. The cause of death could not be determined for nearly half of deaths recorded during follow-up. The lack of homogeneity in patient-level data prevented the inclusion of important variables such as proteinuria and cumulative glucocorticoid dose.<\/p>\n The study did not receive any specific funding. The authors did not declare having any competing interests.<\/p>\n This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n TOPLINE: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) who presented with antimyeloperoxidase (anti-MPO) ANCA appeared to have a higher risk for major adverse cardiovascular events (MACE) and a shorter time to their occurrence than those who presented with antiproteinase 3 (anti-PR3) ANCA. METHODOLOGY: Researchers conducted a retrospective observational study of 402 patients with AAV […]<\/p>\n","protected":false},"author":1,"featured_media":17151,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty-260127-woman-having-heart-ache-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17150"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17151"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}LIMITATIONS:<\/h2>\n
DISCLOSURES:<\/h2>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"