TOPLINE:<\/h2>\n
Access to patient-reported outcome (PRO) data significantly improved providers’ consistency in assessing adverse events in patients with cancer, with the greatest improvements observed for psychological and cognitive symptoms.<\/p>\n
METHODOLOGY:<\/h2>\n\n- Researchers conducted a multinational, open-label, randomised controlled trial including 1067 adult patients with cancer (median age, 59 years; 55.1% women) across 11 hospitals in 10 countries between February 2020 and December 2024.<\/li>\n
- Patients were randomly assigned in a 1:1 ratio to either an intervention group (n = 529), in which providers had access to PRO data, or a control group (n = 538), in which providers did not have access to PRO data.<\/li>\n
- Patients autonomously completed PRO questionnaires once during a day clinic or inpatient stay. Two independent providers engaged in medical encounters with patients and completed Common Terminology Criteria for Adverse Events (CTCAE) ratings.<\/li>\n
- The primary endpoint was the inter-rater reliability of the CTCAE ratings, expressed as intraclass correlation coefficients (ICCs), and secondary endpoints included differences in the frequency of identified adverse events and inter-rater reliability across adverse event types.<\/li>\n<\/ul>\n
TAKEAWAY:<\/h2>\n\n- Inter-rater reliability was significantly higher in the intervention group than in the control group for 13 of 17 symptomatic adverse events, with the largest improvements in ICCs observed for memory impairment (between-group difference in ICC, 0.176; P<\/em> < .0001), irritability (between-group difference in ICC, 0.161; P<\/em> < .0001), and concentration impairment (between-group difference in ICC, 0.157; P<\/em> < .0001).<\/li>\n
- Providers in the intervention group had higher agreement rates for anxiety (68% vs 60%; P<\/em> = .011) and concentration impairment (76% vs 69%; P<\/em> = .011) than those in the control group.<\/li>\n
- Statistically significant differences were observed in the distribution of same-grade ratings between the intervention and control groups for anxiety (P\u00a0<\/em>= .0067), depression (P<\/em> < .0001), concentration impairment (P<\/em> = .0018), memory impairment (P<\/em> < .0001), dyspnoea (P<\/em> < .0001), insomnia (P<\/em> < .0001), nausea (P<\/em> = .045), anorexia (P<\/em> = .038), and peripheral sensory neuropathy (P<\/em> = .003).<\/li>\n
- Researchers noted an unexpected result for diarrhoea, with the control group showing better inter-rater agreement than the intervention group (ICC, 0.758 vs 0.692; P<\/em> =.013).<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
“Future research should explore the implementation of PRO-informed adverse event rating, also in longitudinal assessment settings, its effect on toxicity profiles, and its usefulness in different cancer types and treatment modalities,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Lisa M. Wintner, PhD, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. It was published online on January 19, 2026, in The Lancet Oncology<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
A potential contamination effect existed as providers assessed patients in both the intervention and control groups. The Hawthorne effect may have influenced clinicians to pay more attention to symptom documentation than they would in routine care. High proportions of CTCAE ratings below grade 1 created a floor effect, potentially reducing the statistical power to detect differences in moderate or severe toxicities. Additionally, although providers had at least 1 year of oncology experience, no specific CTCAE training was mandated, potentially contributing to rating variability.<\/p>\n
DISCLOSURES:<\/h2>\n
The trial was funded by a grant from the European Organisation for Research and Treatment of Cancer Quality of Life group. One author reported receiving a grant from the same group. Additional disclosures are noted in the original article.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Access to patient-reported outcome (PRO) data significantly improved providers’ consistency in assessing adverse events in patients with cancer, with the greatest improvements observed for psychological and cognitive symptoms. METHODOLOGY: Researchers conducted a multinational, open-label, randomised controlled trial including 1067 adult patients with cancer (median age, 59 years; 55.1% women) across 11 hospitals in 10 […]<\/p>\n","protected":false},"author":1,"featured_media":17224,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty_221103_doctors_discussion_800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17223"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17224"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
TAKEAWAY:<\/h2>\n\n- Inter-rater reliability was significantly higher in the intervention group than in the control group for 13 of 17 symptomatic adverse events, with the largest improvements in ICCs observed for memory impairment (between-group difference in ICC, 0.176; P<\/em> < .0001), irritability (between-group difference in ICC, 0.161; P<\/em> < .0001), and concentration impairment (between-group difference in ICC, 0.157; P<\/em> < .0001).<\/li>\n
- Providers in the intervention group had higher agreement rates for anxiety (68% vs 60%; P<\/em> = .011) and concentration impairment (76% vs 69%; P<\/em> = .011) than those in the control group.<\/li>\n
- Statistically significant differences were observed in the distribution of same-grade ratings between the intervention and control groups for anxiety (P\u00a0<\/em>= .0067), depression (P<\/em> < .0001), concentration impairment (P<\/em> = .0018), memory impairment (P<\/em> < .0001), dyspnoea (P<\/em> < .0001), insomnia (P<\/em> < .0001), nausea (P<\/em> = .045), anorexia (P<\/em> = .038), and peripheral sensory neuropathy (P<\/em> = .003).<\/li>\n
- Researchers noted an unexpected result for diarrhoea, with the control group showing better inter-rater agreement than the intervention group (ICC, 0.758 vs 0.692; P<\/em> =.013).<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
“Future research should explore the implementation of PRO-informed adverse event rating, also in longitudinal assessment settings, its effect on toxicity profiles, and its usefulness in different cancer types and treatment modalities,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Lisa M. Wintner, PhD, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. It was published online on January 19, 2026, in The Lancet Oncology<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
A potential contamination effect existed as providers assessed patients in both the intervention and control groups. The Hawthorne effect may have influenced clinicians to pay more attention to symptom documentation than they would in routine care. High proportions of CTCAE ratings below grade 1 created a floor effect, potentially reducing the statistical power to detect differences in moderate or severe toxicities. Additionally, although providers had at least 1 year of oncology experience, no specific CTCAE training was mandated, potentially contributing to rating variability.<\/p>\n
DISCLOSURES:<\/h2>\n
The trial was funded by a grant from the European Organisation for Research and Treatment of Cancer Quality of Life group. One author reported receiving a grant from the same group. Additional disclosures are noted in the original article.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Access to patient-reported outcome (PRO) data significantly improved providers’ consistency in assessing adverse events in patients with cancer, with the greatest improvements observed for psychological and cognitive symptoms. METHODOLOGY: Researchers conducted a multinational, open-label, randomised controlled trial including 1067 adult patients with cancer (median age, 59 years; 55.1% women) across 11 hospitals in 10 […]<\/p>\n","protected":false},"author":1,"featured_media":17224,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty_221103_doctors_discussion_800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17223"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17224"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
IN PRACTICE:<\/h2>\n
“Future research should explore the implementation of PRO-informed adverse event rating, also in longitudinal assessment settings, its effect on toxicity profiles, and its usefulness in different cancer types and treatment modalities,” the authors wrote.<\/p>\n
SOURCE:<\/h2>\n
The study was led by Lisa M. Wintner, PhD, Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. It was published online on January 19, 2026, in The Lancet Oncology<\/em>.<\/p>\n A potential contamination effect existed as providers assessed patients in both the intervention and control groups. The Hawthorne effect may have influenced clinicians to pay more attention to symptom documentation than they would in routine care. High proportions of CTCAE ratings below grade 1 created a floor effect, potentially reducing the statistical power to detect differences in moderate or severe toxicities. Additionally, although providers had at least 1 year of oncology experience, no specific CTCAE training was mandated, potentially contributing to rating variability.<\/p>\n The trial was funded by a grant from the European Organisation for Research and Treatment of Cancer Quality of Life group. One author reported receiving a grant from the same group. Additional disclosures are noted in the original article.<\/p>\n This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n TOPLINE: Access to patient-reported outcome (PRO) data significantly improved providers’ consistency in assessing adverse events in patients with cancer, with the greatest improvements observed for psychological and cognitive symptoms. METHODOLOGY: Researchers conducted a multinational, open-label, randomised controlled trial including 1067 adult patients with cancer (median age, 59 years; 55.1% women) across 11 hospitals in 10 […]<\/p>\n","protected":false},"author":1,"featured_media":17224,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/gty_221103_doctors_discussion_800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17223"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17223\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17224"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}LIMITATIONS:<\/h2>\n
DISCLOSURES:<\/h2>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"