TOPLINE:<\/h2>\n
Initiation of calcitonin gene-related peptide (CGRP) inhibitors was associated with a modestly increased risk for a composite of cardiovascular events, and for ischemic stroke alone, compared to noninitiation in patients with migraine, a new US cohort study showed.<\/p>\n
METHODOLOGY:<\/h2>\n\n- A retrospective, observational, nationwide cohort study included data for more than 900,000 adult insurance beneficiaries with migraine (median age, 41 years; 78% women) between 2018 and 2023; nearly 59,000 had initiated use of CGRP inhibitors.<\/li>\n
- Among the CGRP inhibitors, nearly 42,000 used small-molecule CGRP inhibitors and nearly 17,000 used monoclonal antibodies.<\/li>\n
- The primary outcome was a composite of myocardial infarction (MI), cerebral ischemic stroke, revascularization, peripheral arterial disease, or central retinal artery occlusion.<\/li>\n
- Secondary outcomes included the individual events of the composite primary outcome and intracranial hemorrhage. The incidence of humeral fracture was also included as a falsification endpoint.<\/li>\n<\/ul>\n
TAKEAWAY:<\/h2>\n\n- Initiation of a CGRP inhibitor was associated with a higher rate of the composite primary outcome than noninitiation (adjusted hazard ratio [aHR], 1.3; 95% CI, 1.1-1.45).<\/li>\n
- It was also linked to an increased risk for ischemic stroke (aHR, 1.3; 95% CI, 1.1-1.5) \u2014 but not for MI, revascularization, central retinal artery occlusion, intracranial hemorrhage, or humeral fracture.<\/li>\n
- In sensitivity analyses, the use of abortive small-molecule CGRP inhibitors was associated with an increased risk for the composite primary outcome (aHR, 1.3) and ischemic stroke (aHR, 1.4).<\/li>\n
- Preventive CGRP inhibitors were linked to a higher risk for the primary endpoint (aHR, 1.3), MI (aHR, 1.5), and ischemic stroke (aHR, 1.3).<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
\u201cThis study provides class II evidence that in patients with migraine, initiation of a CGRP inhibitor was associated with a modestly increased risk of a composite of cardiovascular events,\u201d the investigators wrote.<\/p>\n
In an accompanying editorial, Samuel W. Terman, MD, University of Michigan, Ann Arbor, Michigan, noted that although all medications have the potential for adverse events, \u201cweighing the complex pros and cons ultimately requires an individualized risk-benefit discussion regarding how much potential benefit is enough, what side effects are common and severe enough to change decisions for an individual patient, and at what price tag.\u201d<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jay B. Lusk, MD, Duke University School of Medicine, Durham, North Carolina. Both the study and the editorial were published online on January 7 in Neurology<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
Because administrative claims data were used, migraine was not well captured and key information on mortality, race, and ethnicity was unavailable, limiting generalizability. Exposure was defined as the first CGRP prescription fill and did not capture adherence patterns or time-varying use. Additional limitations were residual, unmeasured confounding, and the use of a single falsification endpoint.<\/p>\n
DISCLOSURES:<\/h2>\n
The study was funded by the American Heart Association and the Duke University Office of the Provost. Several investigators reported having financial or other ties with various sources, which are fully listed in the original article. The editorialist reported being a past or current paid consultant for Jazz Pharmaceuticals and Xenon Pharmaceuticals.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Initiation of calcitonin gene-related peptide (CGRP) inhibitors was associated with a modestly increased risk for a composite of cardiovascular events, and for ischemic stroke alone, compared to noninitiation in patients with migraine, a new US cohort study showed. METHODOLOGY: A retrospective, observational, nationwide cohort study included data for more than 900,000 adult insurance beneficiaries […]<\/p>\n","protected":false},"author":1,"featured_media":17742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/dt-260203-headache-chest-pain-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17741"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17742"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
TAKEAWAY:<\/h2>\n\n- Initiation of a CGRP inhibitor was associated with a higher rate of the composite primary outcome than noninitiation (adjusted hazard ratio [aHR], 1.3; 95% CI, 1.1-1.45).<\/li>\n
- It was also linked to an increased risk for ischemic stroke (aHR, 1.3; 95% CI, 1.1-1.5) \u2014 but not for MI, revascularization, central retinal artery occlusion, intracranial hemorrhage, or humeral fracture.<\/li>\n
- In sensitivity analyses, the use of abortive small-molecule CGRP inhibitors was associated with an increased risk for the composite primary outcome (aHR, 1.3) and ischemic stroke (aHR, 1.4).<\/li>\n
- Preventive CGRP inhibitors were linked to a higher risk for the primary endpoint (aHR, 1.3), MI (aHR, 1.5), and ischemic stroke (aHR, 1.3).<\/li>\n<\/ul>\n
IN PRACTICE:<\/h2>\n
\u201cThis study provides class II evidence that in patients with migraine, initiation of a CGRP inhibitor was associated with a modestly increased risk of a composite of cardiovascular events,\u201d the investigators wrote.<\/p>\n
In an accompanying editorial, Samuel W. Terman, MD, University of Michigan, Ann Arbor, Michigan, noted that although all medications have the potential for adverse events, \u201cweighing the complex pros and cons ultimately requires an individualized risk-benefit discussion regarding how much potential benefit is enough, what side effects are common and severe enough to change decisions for an individual patient, and at what price tag.\u201d<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jay B. Lusk, MD, Duke University School of Medicine, Durham, North Carolina. Both the study and the editorial were published online on January 7 in Neurology<\/em>.<\/p>\nLIMITATIONS:<\/h2>\n
Because administrative claims data were used, migraine was not well captured and key information on mortality, race, and ethnicity was unavailable, limiting generalizability. Exposure was defined as the first CGRP prescription fill and did not capture adherence patterns or time-varying use. Additional limitations were residual, unmeasured confounding, and the use of a single falsification endpoint.<\/p>\n
DISCLOSURES:<\/h2>\n
The study was funded by the American Heart Association and the Duke University Office of the Provost. Several investigators reported having financial or other ties with various sources, which are fully listed in the original article. The editorialist reported being a past or current paid consultant for Jazz Pharmaceuticals and Xenon Pharmaceuticals.<\/p>\n
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
TOPLINE: Initiation of calcitonin gene-related peptide (CGRP) inhibitors was associated with a modestly increased risk for a composite of cardiovascular events, and for ischemic stroke alone, compared to noninitiation in patients with migraine, a new US cohort study showed. METHODOLOGY: A retrospective, observational, nationwide cohort study included data for more than 900,000 adult insurance beneficiaries […]<\/p>\n","protected":false},"author":1,"featured_media":17742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/dt-260203-headache-chest-pain-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17741"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17742"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
IN PRACTICE:<\/h2>\n
\u201cThis study provides class II evidence that in patients with migraine, initiation of a CGRP inhibitor was associated with a modestly increased risk of a composite of cardiovascular events,\u201d the investigators wrote.<\/p>\n
In an accompanying editorial, Samuel W. Terman, MD, University of Michigan, Ann Arbor, Michigan, noted that although all medications have the potential for adverse events, \u201cweighing the complex pros and cons ultimately requires an individualized risk-benefit discussion regarding how much potential benefit is enough, what side effects are common and severe enough to change decisions for an individual patient, and at what price tag.\u201d<\/p>\n
SOURCE:<\/h2>\n
The study was led by Jay B. Lusk, MD, Duke University School of Medicine, Durham, North Carolina. Both the study and the editorial were published online on January 7 in Neurology<\/em>.<\/p>\n Because administrative claims data were used, migraine was not well captured and key information on mortality, race, and ethnicity was unavailable, limiting generalizability. Exposure was defined as the first CGRP prescription fill and did not capture adherence patterns or time-varying use. Additional limitations were residual, unmeasured confounding, and the use of a single falsification endpoint.<\/p>\n The study was funded by the American Heart Association and the Duke University Office of the Provost. Several investigators reported having financial or other ties with various sources, which are fully listed in the original article. The editorialist reported being a past or current paid consultant for Jazz Pharmaceuticals and Xenon Pharmaceuticals.<\/p>\n This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/em><\/p>\n<\/div>\n<\/div>\n TOPLINE: Initiation of calcitonin gene-related peptide (CGRP) inhibitors was associated with a modestly increased risk for a composite of cardiovascular events, and for ischemic stroke alone, compared to noninitiation in patients with migraine, a new US cohort study showed. METHODOLOGY: A retrospective, observational, nationwide cohort study included data for more than 900,000 adult insurance beneficiaries […]<\/p>\n","protected":false},"author":1,"featured_media":17742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[2],"tags":[],"class_list":["post-17741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/02\/dt-260203-headache-chest-pain-800x450.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=17741"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/17741\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/17742"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=17741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=17741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=17741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}LIMITATIONS:<\/h2>\n
DISCLOSURES:<\/h2>\n
\n
<<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"