{"id":83637,"date":"2026-04-24T19:12:15","date_gmt":"2026-04-24T19:12:15","guid":{"rendered":"https:\/\/diyhaven858.wasmer.app\/index.php\/semaglutide-naion-risk-higher-than-risk-with-sglt2-inhibitors\/"},"modified":"2026-04-24T19:12:15","modified_gmt":"2026-04-24T19:12:15","slug":"semaglutide-naion-risk-higher-than-risk-with-sglt2-inhibitors","status":"publish","type":"post","link":"https:\/\/diyhaven858.wasmer.app\/index.php\/semaglutide-naion-risk-higher-than-risk-with-sglt2-inhibitors\/","title":{"rendered":"Semaglutide NAION risk higher than risk with SGLT2 inhibitors"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div data-component=\"ArticleContent\">\n<div class=\"article__below-title\">\n<div class=\" article__posted-date\">\n<p>April 24, 2026<\/p>\n<p>1 min read<\/p>\n<\/div>\n<div class=\"mobile-trust-box\">\n<div class=\"row\">\n<div class=\"col-12 col-md-5 d-xl-none\">\n<div class=\"trust-box\">\n<div class=\"trust-box-logo d-none d-md-block\">\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/h5\/feature\/news\/publogos\/pcon.svg?la=en&amp;h=28&amp;w=180&amp;hash=9F02AF9127CF86DF7E84A3BCB257547E\" class=\"logo-img\" height=\"28\" alt=\"primary care optometry news logo\" width=\"180\"\/>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"col-12 col-md-6 offset-md-1 offset-xl-0 col-xl-12\">\n<div class=\"email-alert-button-wrapper d-none\" data-component=\"EmailTopicAlert\" data-module=\"Subspecialty Email Topic Alerts Top\" data-manage-email-link=\"\/footer\/account-information\/my-account\/email-subscriptions-and-alerts#emailAlerts\">\n<hidden data-setting-item=\"d265901d-6d37-49c7-a8f6-c7bf19a02509\"\/><br \/>\n<hidden data-crm-source=\"Subspecialty Topic Alert\"\/><\/p>\n<div class=\"email-alert-button d-none\" data-topic-button=\"not-subscribed\">\n<p>\n<span data-module-track-action=\"Email Alerts TOP_Click_Healio News Article\" data-module-track-label=\"Email Alerts TOP_Healio News Article\"><br \/>\n<i class=\"fas fa-plus-circle\"\/><br \/>\nAdd topic to email alerts<br \/>\n<\/span>\n<\/p>\n<div class=\"email-alert-inner collapse ufcdcd0d772bd41c2b61114537480a0fa\">\n<div class=\"email-alert-dialogue\">\n<p>\nReceive an email when new articles are posted on <span data-content=\"topic-title\"\/>\n<\/p>\n<div class=\"d-none\" data-sign-up-type=\"unknown\">\nPlease provide your email address to receive an email when new articles are posted on <span data-content=\"topic-title\"\/>.<\/p>\n<\/div>\n<\/div>\n<p><button type=\"button\" class=\"btn btn-primary\" data-loading-text=\"Loading &lt;i class=\" fa=\"\" fa-spinner=\"\" fa-spin=\"\">&#8221; data-action=subscribe&gt;<br \/>\nSubscribe<br \/>\n<\/button>\n<\/div>\n<\/div>\n<div class=\"d-none\" data-topic-modal=\"failed\"> <strong>We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.<\/strong> <\/p>\n<p><button data-dismiss=\"modal\" class=\"btn btn-primary btn-lg btn-block\">Back to Healio<\/button><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2>Key takeaways:<\/h2>\n<ul>\n<li>Nonarteritic anterior ischemic optic neuropathy risk was 2.33 times higher with semaglutide.<\/li>\n<li>Clinicians need to evaluate visual symptoms and consider ocular risk factors.<\/li>\n<\/ul>\n<p>Semaglutide was associated with more than twice the risk for nonarteritic anterior ischemic optic neuropathy compared with SGLT2 inhibitors, although the absolute risk \u201cremained low,\u201d according to a study published in <i>JAMA Ophthalmology<\/i>.<\/p>\n<p>\u201cAlthough [semaglutide is] effective for glycemic control, weight loss and cardiovascular risk reduction, nonarteritic anterior ischemic optic neuropathy (NAION) has emerged as a serious rare adverse event,\u201d <b>Kent Heberer<\/b><b>, <\/b><b>PhD<\/b><b>,<\/b> data scientist at the U.S. Department of Veterans Affairs, and colleagues wrote. \u201cStudies show conflicting associations.\u201d<\/p>\n<figure class=\"figure article__og-image\">\n<picture><source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.webp?w=476\" media=\"(max-width: 768px)\"><source srcset=\"https:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.webp?w=800\" media=\"(max-width: 992px)\"><source srcset=\"https:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.webp?w=595\" media=\"(max-width: 1200px)\"><source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.webp?w=476\" media=\"(min-width: 1200px)\"><source srcset=\"https:\/\/www.healio.comhttps:\/\/www.healio.comhttps:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.webp?w=476\"><img decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/slack-news\/fm_im\/misc\/infographics\/2024\/01-january\/semaglutide_stock_1200x630.jpg?w=800\" alt=\"semaglutide_STOCK_1200x630\" class=\"figure-img img-fluid\" width=\"800\"\/><br \/>\n<\/source><\/source><\/source><\/source><\/source><\/picture><figcaption class=\"figure-caption\">\nSemaglutide was associated with more than twice the risk for nonarteritic anterior ischemic optic neuropathy compared with SGLT2 inhibitors, although the absolute risk \u201cremained low.\u201d <i>Image: Adobe Stock<\/i><br \/>\n<\/figcaption><\/figure>\n<p>Heberer and colleagues emulated a target trial using nationwide VA data. The analysis included 102,361 veterans with type 2 diabetes, including 11,478 prescribed semaglutide and 90,883 prescribed a sodium-glucose cotransporter 2 (SGLT2) inhibitor.<\/p>\n<p>The researchers compared the incidence of NAION between the two treatment groups across a median follow-up period of 2.1 years.<\/p>\n<p>Overall, the two groups had 173 new cases of NAION. The incidence rate was higher among patients taking semaglutide (123 per 100,000 person-years) than those taking SGLT2 inhibitors (67 per 100,000 person-years).<\/p>\n<p>Compared with SGLT2 inhibitors, patients taking semaglutide had 2.33 times greater risk for NAION (<i>P <\/i>&lt; .001). After adjusting for covariates, the researchers found an overlap-weighted cumulative absolute risk of 0.3% with semaglutide and 0.1% with SGLT2 inhibitors.<\/p>\n<p>The researchers emphasized that the \u201cabsolute incidence remains low,\u201d with about one additional case of NAION for every several thousand patients treated.<\/p>\n<p>\u201cAs clinicians inform patients on semaglutide\u2019s meaningful cardiometabolic benefits, they should also counsel on NAION as a rare, serious vision-loss event,\u201d Heberer and colleagues wrote. \u201cConsistent with recent commentaries, clinicians should encourage prompt evaluation of visual symptoms and consider ocular risk factors (eg, optic nerve disease, prior NAION). Ophthalmologists should identify semaglutide use in patients with NAION, who should inform their prescribing clinicians.\u201d<\/p>\n<div class=\"article__content--footer\">\n<div class=\"publisher-logo\">\n<span>Published by:<\/span><br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.healio.com\/~\/media\/h5\/feature\/news\/publogos\/pcon.svg?la=en&amp;h=28&amp;w=180&amp;hash=9F02AF9127CF86DF7E84A3BCB257547E\" class=\"logo-img\" height=\"28\" alt=\"primary care optometry news logo\" width=\"180\"\/>\n<\/div>\n<div class=\"healio-ai-component-inline\" data-no-ads=\"true\" data-module-track-category=\"Healio AI\" data-module-track-action=\"Click\" data-module-track-label=\"Access Healio Ai from component - News_AI Component - In-Content (all devices)\">\n<div class=\"healio-ai-content\">\n<img decoding=\"async\" src=\"https:\/\/m3.healio.com\/~\/media\/images\/healio-ai\/healio-ai_logo.svg\" alt=\"Healio AI\" class=\"healio-ai-logo\"\/><\/p>\n<p><strong>Ask a clinical question<\/strong> and tap into <strong>Healio AI&#8217;s knowledge<\/strong> base.<\/p>\n<ul>\n<li>PubMed, enrolling\/recruiting trials, guidelines<\/li>\n<li>Clinical Guidance, Healio CME, FDA news<\/li>\n<li>Healio&#8217;s exclusive daily news coverage of clinical data<\/li>\n<\/ul>\n<p><button class=\"healio-ai-button\" onclick=\"window.location.href=\" https:=\"\">Learn more<\/button>\n<\/div>\n<\/div>\n<div class=\"email-alert-button-wrapper d-none\" data-component=\"EmailTopicAlert\" data-module=\"Subspecialty Email Topic Alerts Top\" data-manage-email-link=\"\/footer\/account-information\/my-account\/email-subscriptions-and-alerts#emailAlerts\">\n<hidden data-setting-item=\"d265901d-6d37-49c7-a8f6-c7bf19a02509\"\/><br \/>\n<hidden data-crm-source=\"Subspecialty Topic Alert\"\/><\/p>\n<div class=\"email-alert-button d-none\" data-topic-button=\"not-subscribed\">\n<p>\n<span data-module-track-action=\"Email Alerts TOP_Click_Healio News Article\" data-module-track-label=\"Email Alerts TOP_Healio News Article\"><br \/>\n<i class=\"fas fa-plus-circle\"\/><br \/>\nAdd topic to email alerts<br \/>\n<\/span>\n<\/p>\n<div class=\"email-alert-inner collapse ufcdcd0d772bd41c2b61114537480a0fa\">\n<div class=\"email-alert-dialogue\">\n<p>\nReceive an email when new articles are posted on <span data-content=\"topic-title\"\/>\n<\/p>\n<div class=\"d-none\" data-sign-up-type=\"unknown\">\nPlease provide your email address to receive an email when new articles are posted on <span data-content=\"topic-title\"\/>.<\/p>\n<\/div>\n<\/div>\n<p><button type=\"button\" class=\"btn btn-primary\" data-loading-text=\"Loading &lt;i class=\" fa=\"\" fa-spinner=\"\" fa-spin=\"\">&#8221; data-action=subscribe&gt;<br \/>\nSubscribe<br \/>\n<\/button>\n<\/div>\n<\/div>\n<div class=\"d-none\" data-topic-modal=\"failed\"> <strong>We were unable to process your request. 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