Dobos also thinks the rush to jump on the PDRN bandwagon could be detrimental to the ingredient\u2019s long-term reputation. \u201cWe saw it with CBD in cosmetics, too, frankly; we just weren’t sure of the benefits of it, but it sounded really interesting. This is another case where there’s a lot of hype, but not enough substantiation for me to put my faith in it,\u201d she explains.<\/p>\n
The same could be said for topical exosomes, the other darling of the regenerative skin-care movement: Like PDRN, they are being hyped for their ability to make skin act younger. And like PDRN, the massive claims about exosomes are much bigger than the actual science.<\/p>\n
Does any regenerative skin care work?<\/strong><\/h2>\n<\/p>\nJust because there\u2019s a lack of data on PDRN and exosomes, that doesn\u2019t mean regenerative skin care is a complete hoax\u2014far from it. Decades before PDRN and exosomes were the elements du jour, researchers were amassing data on a handful of ingredients that have since been well-proven to help skin function more efficiently. But back then, those ingredients weren\u2019t labeled as \u201cregenerative\u201d or \u201clongevity\u201d drivers.<\/p>\n
The chemists and dermatologists we spoke with like vitamin C and peptides for boosting skin\u2019s own collagen production; nianiacinamide for regulating cells\u2019 melanin production; and retinoids for\u2026everything, really. Retinoids, a.k.a. vitamin A derivatives, are one family of ingredients backed by decades of research showing they can trigger collagen production and help create skin that looks younger in the long run.<\/p>\n
You\u2019ll probably find at least one of these other ingredients listed alongside PDRN in formula breakdowns. \u201cThat\u2019s essentially how skin care works,\u201d says Romanowski; the ingredients that \u201chelp the marketing people tell a story\u201d get combined with the ones that are actually \u201cproviding the benefits\u2014your petroleum, your mineral oils, your glycerins that nobody wants to talk about.\u201d<\/p>\n
These ingredients may not have the shine of being new and strange, but they do have staying power. The popularity of PDRN, meanwhile, \u201cwill probably fade in a year to two, unless we get some really good data and ways of stabilizing it,\u201d says Dobos.<\/p>\n
But that won\u2019t be easy, or cheap, says Mou: \u201cFormulators would have to work with smaller molecular-weight PDRN, pair it with an optimized delivery system, and the sourcing of the DNA fragments would be of utmost importance. Extraction quality, purity level, uniform fragment size distribution\u2014all of these considerations lead to an increase in the cost of the ingredient.\u201d<\/p>\n
It\u2019s more likely that PDRN will be replaced by the next oddball thing, which will probably come from the biotech world, guesses Romanowski. \u201cThat’s where our industry is going,\u201d he says. \u201cSometimes new ingredients have a lasting impact, but most of the stuff that you’re using now is essentially the same as you were using in the \u201990s. The technology hasn\u2019t changed that<\/em> much.\u201d<\/p>\nIt does, however, get packaged differently and spruced up with the latest trendy ingredient. \u201cThe beauty industry is very much like the fashion industry, where they always need something new,\u201d Romanowski continues. \u201cBut at the end of the day, it’s still pants and shirts.\u201d<\/p>\n
Shop our PDRN product picks<\/strong><\/h2>\n<\/p>\nHere are some of our picks for PDRN-spiked products. We can\u2019t say for sure if PDRN is doing any heavy lifting, but each product includes ingredients that have proven benefits.<\/p>\n
\nMedicube PDRN Pink Collagen Gel Mask<\/strong><\/p>\n<\/div>\n\n\n\n\n\n![\"Medicube](\"https:\/\/media.allure.com\/photos\/69f399a9ce8a177caaf278e8\/3:4\/w_748%2Cc_limit\/Medicube%2520PDRN%2520Pink%2520Collagen%2520Gel%2520Mask.jpg\"\/)
<\/picture><\/span><\/div>\n<\/div>\n<\/div>\n\n\n\nMedicube<\/p>\n
PDRN Pink Collagen Gel Mask<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
PDRN + Glycerin.<\/strong> The exact benefits of PDRN may be unclear, but goodness, does this hydrogel mask feel<\/em> amazing. \u201cHydrogel masks are water and a gelling agent that get mixed together, poured into a mold, and turn into a jelly that\u2019ll evaporate on your skin and feel really nice and cooling,\u201d says Lam. This pink version doesn\u2019t disappoint. \u201cYou wear it overnight and it feels great,\u201d adds Lam, who guesses that PDRN might be suspended in the mask\u2014\u201ca bit like fruit in Jell-O\u201d\u2014while hydrating ingredients such as glycerin make the skin dewy.<\/p>\n\nRejuran Dual Effect Ampoule<\/strong><\/p>\n<\/div>\n\n\n\n\n\n![\"Rejuran](\"https:\/\/media.allure.com\/photos\/69f39bfdaaf4311895fdad2a\/3:4\/w_748%2Cc_limit\/Rejuran%2520Dual%2520Effect%2520Ampoule.jpg\"\/)
<\/picture><\/span><\/div>\n<\/div>\n<\/div>\n\n\n\nRejuran<\/p>\n
Dual Effect Ampoule<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
PDRN + Ceramides.<\/strong> This K-beauty serum is a favorite of Mou\u2019s, who likes that the brand\u2019s clinical testing suggests the formula may help repair the skin barrier and support collagen synthesis. It is made by Rejuran, \u201ca biopharmaceutical company that has a strong presence in Korean skin care,\u201d she notes.<\/p>\n<\/div>\n
\n
<><\/p>\n","protected":false},"excerpt":{"rendered":"
Dobos also thinks the rush to jump on the PDRN bandwagon could be detrimental to the ingredient\u2019s long-term reputation. \u201cWe saw it with CBD in cosmetics, too, frankly; we just weren’t sure of the benefits of it, but it sounded really interesting. This is another case where there’s a lot of hype, but not enough […]<\/p>\n","protected":false},"author":1,"featured_media":87684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3],"tags":[],"class_list":["post-87683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-beauty"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/04\/Allure-Spring-2026-Online-PDRN-Is-Everywhere-All-of-a-Sudden-Cover-Art-FINAL.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=87683"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/87684"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=87683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=87683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=87683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
It does, however, get packaged differently and spruced up with the latest trendy ingredient. \u201cThe beauty industry is very much like the fashion industry, where they always need something new,\u201d Romanowski continues. \u201cBut at the end of the day, it’s still pants and shirts.\u201d<\/p>\n
Shop our PDRN product picks<\/strong><\/h2>\n<\/p>\nHere are some of our picks for PDRN-spiked products. We can\u2019t say for sure if PDRN is doing any heavy lifting, but each product includes ingredients that have proven benefits.<\/p>\n
\nMedicube PDRN Pink Collagen Gel Mask<\/strong><\/p>\n<\/div>\n\n\n\n\n\n<\/picture><\/span><\/div>\n<\/div>\n<\/div>\n\n\n\nMedicube<\/p>\n
PDRN Pink Collagen Gel Mask<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
PDRN + Glycerin.<\/strong> The exact benefits of PDRN may be unclear, but goodness, does this hydrogel mask feel<\/em> amazing. \u201cHydrogel masks are water and a gelling agent that get mixed together, poured into a mold, and turn into a jelly that\u2019ll evaporate on your skin and feel really nice and cooling,\u201d says Lam. This pink version doesn\u2019t disappoint. \u201cYou wear it overnight and it feels great,\u201d adds Lam, who guesses that PDRN might be suspended in the mask\u2014\u201ca bit like fruit in Jell-O\u201d\u2014while hydrating ingredients such as glycerin make the skin dewy.<\/p>\n\nRejuran Dual Effect Ampoule<\/strong><\/p>\n<\/div>\n\n\n\n\n\n<\/picture><\/span><\/div>\n<\/div>\n<\/div>\n\n\n\nRejuran<\/p>\n
Dual Effect Ampoule<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
PDRN + Ceramides.<\/strong> This K-beauty serum is a favorite of Mou\u2019s, who likes that the brand\u2019s clinical testing suggests the formula may help repair the skin barrier and support collagen synthesis. It is made by Rejuran, \u201ca biopharmaceutical company that has a strong presence in Korean skin care,\u201d she notes.<\/p>\n<\/div>\n
\n
<><\/p>\n","protected":false},"excerpt":{"rendered":"
Dobos also thinks the rush to jump on the PDRN bandwagon could be detrimental to the ingredient\u2019s long-term reputation. \u201cWe saw it with CBD in cosmetics, too, frankly; we just weren’t sure of the benefits of it, but it sounded really interesting. This is another case where there’s a lot of hype, but not enough […]<\/p>\n","protected":false},"author":1,"featured_media":87684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3],"tags":[],"class_list":["post-87683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-beauty"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/04\/Allure-Spring-2026-Online-PDRN-Is-Everywhere-All-of-a-Sudden-Cover-Art-FINAL.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=87683"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/87684"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=87683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=87683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=87683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Medicube PDRN Pink Collagen Gel Mask<\/strong><\/p>\n<\/div>\n Medicube<\/p>\n PDRN + Glycerin.<\/strong> The exact benefits of PDRN may be unclear, but goodness, does this hydrogel mask feel<\/em> amazing. \u201cHydrogel masks are water and a gelling agent that get mixed together, poured into a mold, and turn into a jelly that\u2019ll evaporate on your skin and feel really nice and cooling,\u201d says Lam. This pink version doesn\u2019t disappoint. \u201cYou wear it overnight and it feels great,\u201d adds Lam, who guesses that PDRN might be suspended in the mask\u2014\u201ca bit like fruit in Jell-O\u201d\u2014while hydrating ingredients such as glycerin make the skin dewy.<\/p>\n Rejuran Dual Effect Ampoule<\/strong><\/p>\n<\/div>\n Rejuran<\/p>\n PDRN + Ceramides.<\/strong> This K-beauty serum is a favorite of Mou\u2019s, who likes that the brand\u2019s clinical testing suggests the formula may help repair the skin barrier and support collagen synthesis. It is made by Rejuran, \u201ca biopharmaceutical company that has a strong presence in Korean skin care,\u201d she notes.<\/p>\n<\/div>\n Dobos also thinks the rush to jump on the PDRN bandwagon could be detrimental to the ingredient\u2019s long-term reputation. \u201cWe saw it with CBD in cosmetics, too, frankly; we just weren’t sure of the benefits of it, but it sounded really interesting. This is another case where there’s a lot of hype, but not enough […]<\/p>\n","protected":false},"author":1,"featured_media":87684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_daextam_enable_autolinks":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3],"tags":[],"class_list":["post-87683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-beauty"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/diyhaven858.wasmer.app\/wp-content\/uploads\/2026\/04\/Allure-Spring-2026-Online-PDRN-Is-Everywhere-All-of-a-Sudden-Cover-Art-FINAL.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/comments?post=87683"}],"version-history":[{"count":0,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/posts\/87683\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media\/87684"}],"wp:attachment":[{"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/media?parent=87683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/categories?post=87683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diyhaven858.wasmer.app\/index.php\/wp-json\/wp\/v2\/tags?post=87683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<\/picture><\/span><\/div>\n<\/div>\n<\/div>\nPDRN Pink Collagen Gel Mask<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/picture><\/span><\/div>\n<\/div>\n<\/div>\nDual Effect Ampoule<\/h3>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
<><\/p>\n","protected":false},"excerpt":{"rendered":"