This could be a big crossroads in the campaign, because as Juventus and Como were both held to draws, it gives Roma the opportunity to close within a point of fourth place and Champions League qualification.
Neil El Aynaoui is suspended, with Lorenzo Pellegrini, Artem Dovbyk and Evan Ferguson injured, plus Manu Kone, Zeki Celik and Bryan Zaragoza not at 100 per cent.
Fiorentina are on a seven-round unbeaten Serie A run.
Their last two were stalemates against Sassuolo and Lecce, but Moise Kean, Roberto Piccoli, Niccolò Fortini and Tariq Lamptey are all still injured.
Robin Gosens and Fabiano Parisi are back in the squad, but Albert Gudmundsson has to be a False 9 with Jack Harrison and Manor Solomon in support.
Roma vs. Fiorentina line-ups
Roma: Svilar; Mancini, Ndicka, Hermoso; Celik, Cristante, Koné, Wesley; Soulé, Pisilli; Malen
Fiorentina: De Gea; Dodo, Pongracic, Ranieri, Gosens; Ndour, Fagioli, Brescianini; Harrison, Gudmundsson, Solomon
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